pentobarbital will lower the extent or impact of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lower panobinostat levels by ~70% and bring about cure